read James South's resveratrol article

As early as the 1920's Dr. Johanna Brandt wrote a book proclaiming that grapes cured her of cancer. Since then it has been known that there are several beneficial substances in grapes (wine also of course) that assist in lowering cholesterol, reduce the risk of heart disease and have antioxidant abilities.

Resveratrol (chemical formula 3,5,4'-trihydroxy-trans-stilbene) is mainly found in the skin of young unripe red grapes.

Animal studies suggest that Resveratrol can prevent the initiation of cancer and can inhibit the promotion and progression of cancer.

It should be noted that another chemical exists within the grape that is 3,5,4'-trihydroxy-cis-stilbene and that it can also be called Resveratrol. However the -cis- version is not as active as the -trans- version that we offer. IAS's trans-Resveratrol is made by DEDI of Florida, a company synonymous with producing pharmaceuticals and very high quality supplements regardless of cost. We don't believe there is a better quality Resveratrol available anywhere than this brand.

Beware of other Resveratrolís marketed with large capsule dosages such as 50mg, 200mg or even greater. Pure Resveratrol is a difficult and hence expensive substance to produce and what is more clinical trials have normally only used 5,10 or 15mg daily in the trials.

Specifically trans-Resveratrol can help inhibit all three stages of cancer by:

  1. Inducing quinone reductase activity, an enzyme that is capable of detoxifying carcinogens.
  2. Inhibiting cyclo-oxygenase, a substance that causes the production of prostaglandins that stimulate tumor growth, suppress the immune system and activate carcinogens.
  3. Inducing the expression of nitroblue tetazolium reduction activity, a marker of non-specific acid esterase activity and macrophage formation.

Furthermore trans-Resveratrol can inhibit the development of cardiovascular disease. This is performed through its ability as an antioxidant to inhibit platelet aggregation and eicosaniod synthesis and its ability to modulate lipoprotein metabolism.

Resveratrol doses for inhibition (i.e. assistance in the prevention) of cancer and cardiovascular disease are 5mg or 10mg daily. Doses for the treatment of the same are 15mg to 30mg daily.

Caution; Anyone who suffers from platelet deficiency or blood-clotting difficulties or taking blood thinning drugs should only use Resveratrol under medical supervision.

"Resveratrol inhibits cellular events associated with tumor initiation, promotion and progression."
M. Jang et. al "Cancer chemo-preventative activity of resveratrol, a natural product derived from grapes." Science 275, 218-220 (1997)

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