Effect of piracetam on recovery & rehabilitation after stroke: a double-blind, placebo-controlled study. 

Enderby P, Broeckx J, Hospers W, Schildermans F, Deberdt W. 

Speech and Language Therapy Research Unit,
Frenchay Hospital, Bristol, England. 
Clin Neuropharmacol 1994 Aug;17(4):320-31

Abstract

The nootropic agent piracetam has been shown to improve learning and memory, and it may, by this means, facilitate recovery and rehabilitation after a stroke.  We report the results of a pilot study exploring its effects in patients undergoing rehabilitation after acute cerebral infarction in the carotid artery territory.  We compared piracetam and placebo, each given for 12 weeks, in a multi-center, double-blind, randomized trial of parallel-group design; testing was performed at baseline (6-9 weeks poststroke), weeks 5 and 12, and, in fewer patients, 12 weeks after termination of treatment. Standardized tests of activities of daily living (Barthel Index, Kuriansky Test), aphasia (Aachen Aphasia Test), and perception (Rivermead Perception Assessment Battery) were the primary efficacy variables. Of 158 patients, 137 (81 males, 56 females) were studied after treatment and 88 at 24-week follow-up. Thirty patients on piracetam (45%) and 37 on placebo (53%) were aphasic on entry. Both groups, including the subgroups with aphasia, were well matched at baseline for demographic data, stroke sequelae, type and severity of aphasia, and prognostic parameters. Multivariate analysis of Aachen Aphasia subtest scores showed a significant overall improvement relative to baseline in favor of piracetam (p = 0.02) at 12 weeks. This was not seen at 24 weeks when, however, fewer patients were available for evaluation so that we could neither confirm nor deny whether improvement was maintained after cessation of piracetam.  We were unable to demonstrate an effect on tests of activities of daily living and could neither confirm nor exclude an effect on perceptual deficit.  We have shown an improvement in aphasia in patients undergoing rehabilitation after a stroke after 12 weeks' treatment with piracetam that requires confirmation in further studies.


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   Deafness
piracetam  use in sudden deafness
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   Heart Disease
piracetam  in ischemic heart disease
piracetam  effects on arterial hypertension
piracetam  effect on elderly coronary heart disease
piracetam  in chronic ischemic heart disease
piracetam  in ischemic heart disease
piracetam  in myocardial infarct patients
   Mental Function
piracetam  in patients with mental decline
piracetam  effects on cognitive functions
piracetam  efficacy in cognitive impairment
piracetam  in cerebral impairment
piracetam  study age-related memory disorders
piracetam  a trial on memory impairment
piracetam  interaction in the motor cortex
piracetam  effects on human EEG
piracetam  and EEG of boys with learning disorders
piracetam  effect on adolescent brain function
piracetam  in elderly cerebral impairment
piracetam   changes brain function
piracetam  effects on brain functions
   Stroke
piracetam  improves blood flow of post-stroke patients
piracetam  in secondary stroke prophylaxis
piracetam  treatment of acute and chronic aphasia
piracetam  in the treatment of acute stroke
piracetam  evaluation in acute stroke
piracetam  in stroke-unduced Aphasia
piracetam  treatment in ischemic stroke
piracetam  treatment of patients with an ischemic stroke
piracetam  acute stroke study
piracetam  effect on post-stroke recovery
piracetam  adjuvant to language therapy for aphasia
piracetam  effect on cerebral infarction in stroke patients
   Sickle cell disease
piracetam  treatment of children with sickle cell disease
piracetam  improves sickle cell deformability
piracetam  crises management of sickle cell disease
   Child birth
piracetam  in parturients and newborn infants
piracetam  reduced duration of labor
piracetam  protective effect during delivery
piracetam  concentrations during delivery
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piracetam  in patients with myoclonus
piracetam  relieves symptoms in progressive myoclonus epilepsy
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piracetam  beneficial effect on post-ischaemic myoclonus
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piracetam  treatment of Raynaud's
piracetam  evidence for its anti-platelet effect in Raynaud's
piracetam  platelet anti-aggregant properties
   Vertigo
piracetam  treatment for vertigo
piracetam  is effective in vertigo
piracetam  effect in 55 vertigo patients
piracetam  subjective improvement in vertigo
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