NOW Foods' Quercetin is from a non-citrus
source. This makes it quite suitable for persons
with allergies, especially to citrus fruits.
Bromelain, a pineapple-derived enzyme, is
added to enhance the absorption of Quercetin
salt, yeast, wheat, corn, milk, preservatives.
Other Ingredients: Cellulose,
Magnesium Stearate, Silica
u p p l e m e n t F a c t s
Size: 2 Vcaps
Servings Per Container:
Quercetin (as Quercetin Dihydrate)
Bromelain (2,000 GDU)
Percent Daily Values are based on 2,000 calorie
† Daily Value not established.
Quercetin has been shown to be active against many types of cancer
including: breast, prostate, colon, gastric, head and neck, leukemia, lung
melanoma, liver, ovarian, cervical, rhabdomyosarcoma and it damages cancer
cells only. In addition to its powerful antioxidant activity it is a
potent aromatase inhibitor. Quercetin inhibits production of estrogen from
DHEA and testosterone and also inhibits estrone sulfatase in the liver. It
has anti-inflammatory effects and could help the muscle and joint pain
associated with CFS. It also has strong anti-histamine activity and could
improve the environmental and chemical sensitivities associated with CFS.
It is immunostimulatory and antiviral against CMV, EBV, HIV, poliomyelitis
and herpes simplex I & II. It blocks RNA transcriptase, impedes viral
replication and increases reduced intracellular glutathione. Quercetin is
non-toxic and the major flavonoid found in the US diet. It is estimated
that Americans can consume approximately 25 mg/day. The therapeutic dose
ranges from 2000 to 4000 mg/day.
excerpts from Quercetin - Resveratrol
by James South
Quercetin has also shown potent anti-cancer activity. Quercetin has "been shown
to inhibit the growth of cells derived from human and animal cancers,
such as leukemia and Ehrlich ascites tumors, the estrogen
receptor-positive breast carcinoma (MCF-7), squamous cell carcinoma of
head and neck origin, gastric cancer and colon cancer, as well as human
leukemia HL-60 cells in culture [Vang et al reported resveratrol to be active in
normalizing HL-60 cells in culture back into normal cells].... Quercetin
has antiproliferative activity against breast and stomach cancer cell
lines and human ovarian cancer primary cultures and can potentiate the
action of [the anti-cancer drug] cisplatin ex vivo....
Hoffman et al in 1988 related both quercetin's direct anti-cancer activity, as
well as its synergistic effect with several standard anti-cancer drugs
to its ability to inhibit the enzyme protein kinase C. They also noted
that Quercetin "...is a licensed [anti-cancer] drug in many countries,
and is non-toxic at the required dose range." (20).
CANCER/ BLOOD/ ANTIOXIDANT CONNECTION
In his textbook Cancer & Natural Medicine, J. Boik reports the
importance of platelet aggregation and eicosanoid issues in cancer. Thus
he writes: "The importance of platelet aggregation in cancer
metastasis is more widely accepted.... Activated platelets are sticky
and may enhance the adhesion of tumor cells to the endothelial lining.
Platelet-secreted factors... may stimulate the growth of tumor cells and
contribute to their survival within the blood circulation. Experimental
studies have shown that migrating cells from some cancers induce
platelet aggregation by modifying the eicosanoid balance.... Tumors
promote platelet aggregation by stimulating the production of PGI2....
Tumors synthesize eicosanoids through both the [COX and LOX] pathways.
The [LOX] pathway of [AA] is important, if not essential, to tumor
promotion." (23). Given the prior discussion in this article of resveratrol
as premier COX-inhibitor and quercetin as premier LOX-inhibitor, and both as
excellent anti-platelet aggregators, their combined potential
anti-cancer benefit should be evident.
Hollman, et al recently completed a study of Quercetin absorption in healthy
ileostomy patients with complete small intestines. They found a 100mg
dose of pure Quercetin to be absorbed approximately 24%. (24).
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