Alpha Lipoic Acid

Alpha Lipoic Acid is a sulfurous fatty acid that would have been classified as a Vitamin except for the fact that it can be synthesized within the human body.

Lipoic Acid helps to prevent Age-Related Macular Degeneration (ARMD) (due to the Antioxidant properties of Lipoic Acid; Lipoic Acid can penetrate eye tissue and protect both the Lens and the Retina from degeneration).

Lipoic Acid protects the lens and retina of the eye from degeneration.

Lipoic Acid alleviates Glaucoma (after 1 month of treatment with 150 mg of Lipoic Acid per day 47% of persons with Glaucoma exhibited improvement in visual acuity, visual field color discrimination and increased lacrimal tear fluid)

Lipoic Acid reduces the incidence of cataracts in persons with Diabetes.   
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Lipoic Acid normalizes blood sugar levels.

Lipoic Acid (300 - 600 mg per day) reduces Insulin Resistance (i.e. it increases Insulin sensitivity).
Lipoic Acid prevents and alleviates many of the detrimental side effects that occur as a result of Diabetes Mellitus (both Type 1 and Type 2).

Lipoic Acid prevents the (diabetic) Neuropathy that is a common side effect of Diabetes Mellitus [Lipoic Acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy].

Lipoic Acid is a potent scavenger of Hydroxyl Free Radicals.

Lipoic Acid inhibits the cross-linking of the body’s Proteins.

Lipoic Acid is used therapeutically to treat Liver ailments and it protects the Liver from the toxic effects of many Pharmaceutical Drugs.

Lipoic Acid is an effective therapy in the treatment of food poisoning by toxic mushrooms.

Lipoic Acid helps to recycle Vitiams C and E.

References                                         to order

Baur, A., et al. Alpha-lipoic acid is an effective inhibitor or human immuno-deficiency virus (HIV-1) replication. Klin Wochenschr . 69:722-724, 1991.

· Fuchs, J., et al. Studies on lipoate effects on blood redox state in human immunodeficiency virus infected patients. Arzneim Forsch. 43:1359-1362, 1993.

· Ou, P., et al. Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant? Biochem Pharmacol. 50:123-126, 1995.

· Packer, L. Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts. Annals NY Acad Sci. 738:257-264, 1994.

· Packer, L., et al. Alpha-lipoic acid as a biological antioxidant. Free Rad Biol Med. 19:227-250, 1995.

· Shih, J. C. H. Atherosclerosis in Japanese quail and the effect of lipoic acid. Fed Proc. 42:2494-2497, 1983.

· Suzuki, Y. J., et al. Lipoate prevents glucose-induced protein modifications. Free Rad Res Comms. 17:211-217, 1992.

· Kawataba, T., et al. Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein. Biochem Biophys Res Comm. 203:99-104, 1994.

· Xu, D. P., et al. Alpha-lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria. J Bioenerg Biomembr. 28(1):77-85, 1996.

· Faust, A., et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 16(1):61-66, 1994.

· Jacob, S., et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittel-Forschung. 45:872-874, 1995.

· Jacob, S., et al. The antioxidant -lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes. 45:1024-1029, 1996.

· Wagh, S. S., et al. Mode of action of lipoic acid in diabetes. Journal of Bioscience. 11:59-74, 1987.

· Ziegler, D., et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care. 20(3):369-373, 1997.

· Altenkirch, H., et al. Effects of lipoic acid in hexacarbon-induced neuropathy. Neurotoxicol Teratol. 12:19-22, 1990.

· Nagamatsu, M., et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 18:1160-1167, 1995.

· Filina, A. A., et al. Lipoic acid as a means of metabolic therapy of open-angle glaucoma. Vestnik Oftalmologii, 111:68, 1995.

· Haugaard, N., et al. Stimulation of glucose utilization by thioctic acid. Biophys Acta. 222:583-586, 1970.

· Matsugo, S., et al. Elucidation of antioxidant activity of alpha-lipoic acid toward hydroxyl radical. Biochem Biophys Res Comm. 208:161-167, 1995.

· Wolz, P., et al. Neuropharmacology. 35:369-375, 1996.

· Ou, P., et al. Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant? Biochem and Pharmacology. 1(123):123-126, 1995.

· Xu, D. P., et al. Alpha-lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria. J Bioenerg Biomembr. 28(1):77-85, 1996.

· Podda, M., et al. Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem Biophys Res Comm 204:98-104, 1994. 

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