Galantamine Helps Save
Memory, and Money Too
by Will Block
We're always looking for an edge - something that gives us a special advantage. It's human nature. Consider the humble chair: it serves only one purpose (OK, two, if you happen to be a lion tamer): you sit on it.
matter which of the zillion different designs that chair has, it's still just a chair. Then some genius looks at chairs in a new way, says, "I can do better than that," and invents the
Instant edge! People flock to it. They don't just sit on it, they lounge on it. Although it doesn't make ordinary chairs obsolete, it sets a new standard that no previous chairs can match, because it can do something
they can't do.
Galantamine is like that. It's not just an acetylcholinesterase inhibitor (a what?), but an acetylcholinesterase inhibitor that's better than the others, in part because it can do something they can't
do: it can modulate nicotinic receptors in the cholinergic system, making it more effective in combating Alzheimer's disease than drugs such as donepezil and
Sorry! If you choked on some of the terms we just threw at you, fear not - we'll explain them.
For starters, galantamine is an alkaloid extracted (at considerable cost, by the way) from flowers such as the snowdrop (Galanthus
nivalis), the daffodil (Narcissus pseudonarcissus L.), and the spider lily (Lycoris
radiata). It has a long history of use, going back many centuries, for a variety of medicinal purposes, particularly the
alleviation of neuromuscular ailments such as neuritis and neuralgia.
WHY GALANTAMINE IS OUR FRIEND
In modern times, scientific interest in galantamine has focused on its benefits for treating jet lag,1 fatigue syndrome,2
and even impotence.3
By far the greatest interest, however, is devoted to galantamine's use in treating Alzheimer's disease, because of its
exceptional qualities as an acetylcholinesterase inhibitor (AChEI).4 That means that it's a substance that inhibits the biochemical action
of acetylcholinesterase (AChE). And that's good.
Acetylcholinesterase is an enzyme that destroys acetylcholine
(ACh). That's bad (relatively speaking). ACh, as you may know, is one of the body's and brain's most important neurotransmitters - a carrier of nerve
impulses across the tiny gaps, called synapses, between one nerve cell (neuron) and the next. ACh facilitates memory, among other things. That's good.
Did you follow that good/bad/good sequence?
OK, think of it again, in reverse, like this: ACh is good because it's a vital neurotransmitter and is crucial to memory.
AChE is bad because it destroys ACh (not all of it, just some
of it). And galantamine is good because it inhibits AChE from doing that (which makes galantamine an AChEI).
It's like the old saying, "The enemy of my enemy is my friend."
To anyone facing the prospect of Alzheimer's
disease, there is probably no greater friend than galantamine. Let's see why that’s true.
GALANTAMINE, MEET THE CHOLINERGIC SYSTEM
The part of the nervous system for which acetylcholine acts as the sole or primary neurotransmitter - and that means the great majority of the entire nervous system, peripheral as well as central - is called the cholinergic
system. In this article, our interest is in the brain portion of the cholinergic system, because that is where Alzheimer's disease strikes. And where Alzheimer's strikes, galantamine - better than anything else - acts
to thwart it.
Alzheimer's disease, the most prevalent form of dementia, is due in part to a deficiency of acetylcholine in certain parts of the brain. This robs its victims of memory and other vital aspects of cognitive function, including
the ability to perform many of the mundane tasks of daily living. It can also rob them of several years of their life, as a recent Canadian study has shown.5
Whenever ACh deficiency is mentioned, one thinks right away of
AChE, the enzyme that destroys ACh. It's not that AChE is intrinsically bad - on the contrary, it's absolutely essential for good health and for life itself - but
that its effect can be bad if it gets the upper hand in the never-ending balancing act between itself and
ACh. In the exquisite biochemistry of the brain, ACh is constantly being formed in the synapses and is just as
constantly being "mopped up" by AChE.
The incentive to find better acetylcholinesterase inhibitors is
tremendous. And that's where galantamine comes in.
If AChE does manage to gain the upper hand, we want to restore the balance by using an AChEI
(acetylcholinesterase inhibitor, remember?). This is, in fact, the only significant pharmacological intervention used for Alzheimer's
disease in modern medical practice. The incentive to find better AChEIs, therefore, is tremendous. And that's where galantamine comes in.
GALANTAMINE BOOSTS ACETYLCHOLINE
Galantamine doesn't destroy AChE (if it did that, there would be havocin our brains).
It just slows it down some, thereby giving ACh levels a boost - a much-needed boost if they are low because of Alzheimer's disease or
any other form of age-related cognitive impairment. So far, so good.
But other AChEIs can do that too. The two that are most commonly used for Alzheimer's are the prescription drugs donepezil and rivastigmine (the drug tacrine is
rarely prescribed any more, owing to its severe side effects, especially liver damage).
GALANTAMINE MODULATES NICOTINIC RECEPTORS
Now we've explained all the terms in that "choker" paragraph except one: nicotinic receptors.
We saved the best for last, because this is where galantamine gains its special edge, by doing something that
donepezil and rivastigmine can't do: galantamine modulates nicotinic receptors (we'll explain them in a moment), thereby enhancing the effectiveness of acetylcholine as a neurotransmitter.6,7
AN ELECTRIFYING STORY
Here's how it works. A nerve impulse, in the form of a tiny electric current, propagates down the length of a neuron.
(Don't get us started on how that impulse got started - there's only so much we can cover in one article.) When
it reaches the end, it causes a swarm of acetylcholine molecules to be released into the synapse. As the molecules diffuse across that tiny gap, their "mission" is to stimulate the ending of the neuron they're
approaching, thereby initiating another tiny electric current that will propagate down the length of that neuron to the next synapse, and so on until the signal reaches its destination.
Galantamine's ability to make more acetylcholine available and to make the acetylcholine receptors more sensitive is why it is so effective against Alzheimer's
But how does a neurotransmitter stimulate a nerve ending?
The answer lies in receptor sites. These are highly specialized protein complexes that dot the surface of the nerve ending, waiting for neurotransmitter
molecules to show up and "turn them on," with literally electrifying results.
The receptors are sensitive only to their particular kind of neurotransmitter or to molecules that mimic them.
Sometimes, however, other molecules can modulate the properties of receptor sites, through chemical interactions, in such a way as to make them even more sensitive to their designated neurotransmitter. When that occurs,
nerve impulses travel more surely and efficiently, and cognitive function is enhanced.
WHY GALANTAMINE TOPS THE LIST IN FIGHTING ALZHEIMER'S
For acetylcholine molecules, there are two main kinds of neuronal receptors: nicotinic receptors and muscarinic receptors.
We'll spare you the details; suffice it to say that the nicotinic receptors (so named
because they are very sensitive to the brain-stimulating nicotine molecule) can be modulated - sensitized, if you will - by
Neither donepezil nor rivastigmine, however, has that capability.
How Galantamine Can Save Money
Associated with every disease are significant costs. There are financial burdens, of course, but also the loss of emotional
well-being, and the toll that that can take on one's family and friends, as well as one's self. This is particularly true of dementias, such as Alzheimer's, whose insidious action erodes their victims' personalities by robbing
them of their life's memories and even of their sense of who they are. It is an awful thing to endure, or to witness.
As the disease progresses and cognitive functions deteriorate, patients need more and more physical care to get through the day. Eventually they may become so dependent that full-time care is required. The financial cost of
that, of course, is great. Thus it is useful to evaluate the extent to which therapy can delay the time when full-time care becomes necessary. A further consideration is the extent to which the level of that care, and thus its
cost, can be reduced through the beneficial effects of ongoing therapy - taking the cost of the therapy itself into account, of course.
A study of the use of galantamine therapy (24 mg per day) compared with no pharmacological therapy has addressed these questions for Canadian patients with mild to moderate Alzheimer's disease.1
Using data from two prior placebo-controlled clinical trials of 6 months duration,2,3 the researchers went to great lengths to devise reasonable
assumptions and equations upon which to base computations of probable long-term costs over a 10-year period.
To make a long and complicated story short, the computer model devised for this study predicted that galantamine therapy would reduce the duration of full-time care by almost 10% over the 10-year period.
When all patients were
considered in the computations, the savings per patient averaged $528. When only those patients with moderate Alzheimer's were considered, however,the savings were much greater, rising to $2533.
The model results also predicted that patients treated with galantamine were likely to remain at home longer, and thus spend less time in nursing homes. These results were sustained over a broad range of input parameters.
The researchers concluded that "Galantamine cannot only potentially increase the time before patients require full-time care, but may also lead to overall savings because treatment costs are offset by reductions in other
health care expenditures."
- Getsios D, Caro JJ, Caro G, Ishak K. Assessment of health economics in Alzheimer's disease (AHEAD): galantamine treatment in Canada. Neurology 2001;57:972-8.
- Raskind MA, Peskind ER, Wessel T, Yuan W, and the Galantamine USA-1 Study Group.
Galantamine in Alzheimer's disease: a 6-month, randomized, placebo-controlled trial with a 6-month extension.. Neurology 2000;54:2261-8.
- Wilcock GK, Lilienfeld S, Gaens E, on behalf of the Galantamine International-1 Study Group. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: a
multicenter, randomized, controlled
trial. Br Med J 2000;321:1-7.
The importance of this aspect of galantamine's action is underscored by the fact that, with advancing age, our nicotinic receptors tend to decrease both in number and in sensitivity. Thus, galantamine's ability not only to make
more ACh available, by inhibiting AChE, but also to make the ACh receptors more sensitive to the neurotransmitters, represents a unique bonus. And that is why galantamine is the most effective AChEI currently in use against
NEW EVIDENCE OF GALANTAMINE'S EFFICACY
New evidence of galantamine's value comes from a randomized, double-blind, placebo-controlled trial to evaluate the efficacy and tolerability of galantamine taken at three different dosages - 18, 24, and 36 mg per day - for 3
months.8 The subjects were 285 patients (males and females over 45 years of age, with an average age of 74) divided into four groups: one for each
of the three dosages, plus a control group.
All the subjects had mild to moderate Alzheimer's disease, and they were screened to exclude those who had dementia that might be due to any other cause, such as vascular dementia.* Also
excluded were those who were taking any kind of drug that might cloud the interpretation of the results, such as antidepressants,
antipsychotics, sedatives, and most antihypertensives.
COGNITIVE FUNCTION AND QUALITY OF LIFE ARE IMPROVED
The researchers evaluated the patients' condition at baseline (the beginning of the study) and again after 6 and 12 weeks, by means of standardized tests of cognitive function and activities of daily living (the latter can be used
as indicators for an overall quality-of-life assessment). They found that at all dosages, galantamine significantly improved the patients' condition, with the greatest gains being realized at the intermediate, 24-mg dose
(demonstrating yet again that more is not always better).
The authors concluded that ". . . the favorable effects of galantamine on patients' quality of life confirm that its effects on cognitive function are clinically relevant." In their opinion, the 24-mg dose is optimal
for the treatment of Alzheimer's disease, based on both the efficacy and tolerability results. This view is supported by a previous, long-term study showing that 24 mg per day of galantamine preserves patients' cognitive and
functional abilities at baseline levels for at least 12 months.9 The present authors point out, however, that 16 mg per day may be adequate for some
SUPPLEMENTERS, TAKE NOTE
One feature of the study's design is especially worth noting for anyone who might be contemplating the use of galantamine as a dietary supplement. Although the study lasted for 12 weeks, the patients did not receive the full
dosages of galantamine for that entire period. With galantamine it is preferable to start small and build to the desired dosage gradually, so as to allow the body to adjust to its new condition and to minimize potential side
In the study, the patients started by taking 4 mg of galantamine twice daily. The dosages were increased at 2-to-3-day intervals until the target levels of 6, 8, and 12 mg three times daily were reached (after 5, 8, and 14
days, respectively). This dose-escalation period was followed by 10 weeks of full dosage for all the patients.
GALANTAMINE IS WELL TOLERATED AND SAFE
Overall, the galantamine was well tolerated, although the authors admitted that the fairly short dose-escalation period of 1-2 weeks may have affected the tolerability adversely, especially in the highest-dose group. Side effects
of the treatment, consisting mainly of mild and transient nausea and other symptoms of gastrointestinal upset, occurred mainly during the dose-escalation period. Thereafter the incidence of side effects declined rapidly to levels
similar to those associated with placebo.
At all dosages, galantamine
significantly improved the
patients' condition, with the
greatest gains being realized at
the intermediate, 24-mg dose.
Laboratory tests showed no clinically relevant changes. In particular, there were no indications of liver damage (and there never have been in any studies with
galantamine). Liver damage used to be a major concern in
Alzheimer's therapy when tacrine was used, but that has become a
nonissue, because none of the Alzheimer's drugs now in common use cause liver damage.
GALANTAMIND CONTAINS GALANTAMINE AND MORE
Fortunately for American consumers, galantamine is available in the United States without a prescription, even though it was brought to market as a prescription drug in 2001, under the name Reminyl®.
For a significantly lower price, high-purity galantamine is available as
GalantaMind. Unlike Reminyl, GalantaMind is augmented with the acetylcholine precursor choline, together with choline's vital cofactor, pantothenic
acid (vitamin B5).
GalantaMind thus enhances acetylcholine levels both directly, by stimulating its production, and indirectly, by protecting what is already there. And, as we have seen, it does what other acetylcholinesterase inhibitors can't
do: it enhances the efficiency of acetylcholine use in the brain by modulating those nicotinic receptors. So don't just sit there. Get up off your BarcaLounger and get some
GalantaMind. As supplements go, it
could become your best friend.
- Davis BM. Method for alleviating jet lag. US Patent 5,585,375, issued Dec. 17, 1996.
- Snorrason E. Treatment of fatigue syndrome. US Patent 5,312,817,issued May 17, 1994.
- Katz R. Method of treating physiologic male erectile impotence. US Patent 5,177,070, issued Jan. 5, 1993.
- Olin J, Schneider L. Galantamine for Alzheimer's disease (Cochrane review). In The Cochrane Library, Issue 2, 2001. Oxford: Update Software.
- Wolfson C, Wolfson DB, Asgharian M, M'Lan CE, Østbye T, Rockwood K, Hogan DB. A reevaluation of the duration of survival after the onset of dementia. N Engl J Med 2001 Apr 12;344(15):1111-6.
- Maelicke A, Samochocki M, Jostock R, Fehrenbacher A, Ludwig J, Albuquerque EX, Zerlin M. Allosteric sensitization of nicotinic receptors by
galantamine, a new treatment strategy for Alzheimer's disease. Biol Psychiatry
- Coyle J, Kershaw P. Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's
disease. Biol Psychiatry 2001;49:289-99.
- Wilkinson D, Murray J, in collaboration with the Galantamine Research Group. Galantamine: a randomized, double-blind, dose comparison in patients with Alzheimer's disease. Int J Geriatr Psychiatry 2001;16:852-7.
- Raskind MA, Peskind ER, Wessel T, Yuan W, and the Galantamine USA-1 Study Group.
Galantamine in Alzheimer's disease: a 6-month, randomized, placebo-controlled trial with a 6-month extension. Neurology 2000;54:2261-8.